• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A system for storing and dispensing a NO / N2 gas mixture comprising a cylindrical shaped container (6) containing a gaseous mixture of NO and nitrogen, and an expansion valve integrated fitting (8) comprising a metal valve body (23) with at least one internal gas passage (22), said integral pressure regulating valve (8) being fixed to the packaging container (6). At least the portion of the valve body (23) traversed by said internal gas passage (22) is made of stainless steel. The invention also relates to an installation for dispensing a gas containing NO to a patient comprising a ventilator (1) delivering an oxygen-containing gas, and a system for storing and dispensing a gaseous mixture formed of NO / N2 according to the invention.
    公开号:FR3015000A1
    申请号:FR1362490
    申请日:2013-12-12
    公开日:2015-06-19
    发明作者:Villemeur Pierre De；Laurent Lecourt；Catherine Beseme
    申请人:Air Liquide Sante International SA；
    IPC主号:
    专利说明:

    [0001] The invention relates to a system for storing and dispensing a NO / N2 gas mixture comprising an integrated pressure reducer valve or "RDI" made of stainless steel mounted on a gaseous mixture of NO and nitrogen gas conditioning container. concentration of at least 200 ppmv (ppm by volume) and up to 3500 ppmv, and at a pressure of 100 to 500 bar.
    [0002] NO gaseous is conventionally used at different concentrations ranging from 200 to 1000 ppm by volume (hereinafter "ppmv"), the rest of the gaseous mixture being nitrogen, to treat pulmonary vasoconstrictions, including pulmonary hypertension in patients undergoing cardiac surgery or hypoxic newborns. In this respect, mention may be made of EP-A-786264 and EP-1516639.
    [0003] The gaseous NO / nitrogen mixture is generally conditioned at a pressure of the order of 100 to 200 bar absolute in a container, such as a gas cylinder, equipped with a valve block for controlling the gas outlet of said container. Given its very high pressure, the gas must be relaxed before administration to the patient so as to reduce its pressure and make it compatible with administration by inhalation. To do this, a gas expander is used that is either fixed at the outlet of the tap or integrated with a NO administration and monitoring device, located downstream of the valve being connected thereto by a high pressure type hose. . These systems pose some problems.
    [0004] Thus, when the pressure reducer is connected to the valve by a hose, this hose causes a risk of injury to users because of the high pressure it carries because it can be a source of mishandling. In addition, a significant volume of gas can be contained in a hose containing high pressure gas, which potentially leads to NO2 formation and therefore requires a regular bleed hose. In the case where the pressure reducer is attached to the outlet of the tap, there is the problem of congestion because this regulator is an additional element to connect to the tap, which can for example annoy users. In addition, there is also a risk associated with the high pressure of the gas, when installing the regulator on the bottle. It should be possible to use the NO gas mixture very quickly. From there, either the regulator is left permanently on the bottle, which gives rise to a risk of damage if the bottle falls, or it is installed afterwards, but in this case, the installation time will delay the start. treatment. The problem to be solved is then to be able to achieve a reduction in the pressure of the NO-based gas mixture without encountering all or part of the aforementioned problems. The solution is a system for storing and dispensing a NO / N2 gas mixture comprising: a conditioning vessel containing a gaseous mixture of NO and N 2, typically the gaseous mixture NO / N 2 contains 200 at 3500 ppm by volume of NO and nitrogen for the rest, and - an integrated regulator valve (RDI) comprising a metal valve body 20 comprising a gas inlet, at least one gas outlet and at least one internal gas passage through said valve body for fluidly connecting the gas inlet to said at least one gas outlet, said integral pressure regulator valve being attached to the conditioning container, characterized in that at least the body portion of the The valve through which said internal gas passage passes is made of stainless steel. Thanks to the present invention, the users are no longer exposed to the high gas pressure because the gas is expanded directly into the integrated expansion valve and therefore leaves at low pressure, that is to say typically between 1 and 10 bar abs. for example between 2 and 7 bar abs. The low pressure can be set at a desired level thereby enabling the NO delivery system powered by the expanded gas to operate properly.
    [0005] In addition, this also avoids the risk of improper handling existing with the prior valves and the low pressure output of the pressure reducer can be connected directly to a NO administration and monitoring system. In addition, the solution of the invention also makes it possible to obtain a reduction in the overall bulk because no addition of an additional pressure reducer at the outlet of the tap is no longer necessary. Depending on the case, the system of the invention may comprise one or more of the following technical characteristics: the body is entirely made of stainless steel. The use of stainless steel as a constituent material of the passages and other elements in contact with the NO-based gas is advantageous because it avoids or minimizes the corrosion of the elements of the pressure reducer valve. due to the corrosive nature of NO / gas. it comprises at least two gas outlets, that is to say outlet fittings, comprising a pressure output and a flow output. the conditioning container is of cylindrical shape. the conditioning container comprises a bottom and a neck with an outlet orifice at the level of which the integrated regulator valve is fixed. - the integrated regulator valve is protected by a protective cover. - The integrated pressure regulator valve further comprises means for adjusting the expansion of the gas. a marking or a given coloration makes it possible to identify the concentration of NO. - A coding system avoids the risk of error connection to the integrated pressure regulator valve, that is to say the low pressure output of the RDI. - The integrated pressure regulator valve further comprises means for controlling the release of the gas. the means for adjusting the expansion of the gas and / or the means for controlling the release of the gas comprise one or more rotary members that can be actuated manually by a user. the means for adjusting the expansion of the gas cooperate with an expansion valve. - The valve cooperates with a valve seat - the expansion valve and / or the valve seat are made of stainless steel. - the conditioning container with an internal volume of less than or equal to 20 liters (water equivalent), preferably an internal volume less than or equal to 15 liters (water equivalent) and greater than or equal to 0.5 liters (water equivalent) ). it may comprise a device for monitoring the autonomy of the bottle in volume (liters) and / or in time (hours and / or minutes). it comprises a device for monitoring the autonomy of the bottle designed to communicate autonomy information, notably one or more autonomy information, in particular time and / or volume information, to one or other systems, in particular a delivery device, a computer or a remote server. The autonomy information can be transmitted to a delivery device for example by infrared, wired, Bluetooth, GSM, GPRS or other. the integrated pressure reducing valve comprises an outlet connection for the gas at low pressure, that is to say between 1 and 10 bar absolute, typically between 2 and 7 bar, preferably from 3 to 5 bar, and with flow rate adjustable. the integrated pressure reducing valve comprises an outlet connection for the low-pressure gas comprising means of detrumping, for example a particular profile or the like. - The integrated pressure regulator valve further comprises a fixed given flow output connector comprising one or more calibrated orifices selectable to allow a non-adjustable fixed rate gas NO delivery. Such a system delivering only 1 or 2 rates allows use in degraded mode or "backup", in case of failure of an NO delivery device connected to the low pressure output of the RDI. In this "backup" mode, the flow rates can be set for example between 200 and 250 ml / min for adult patients or neonates ventilated with ventilators in OHF mode (high frequency oscillations) and between 100 and 150 ml / min for children or newborns ventilated by conventional ventilation. Indeed, such flow rates correspond to a concentration of 2 to 20 ppmv for minute volumes adapted to the patient in question, namely from 2 to 30 liters for example. For a more accurate delivery in the context of use without a sophisticated NO delivery device (eg use in emergency vehicles (ambulance or helicopter), a more complete flow meter section can also be added to the RDI. a range of 10 to 15 preselected rates (for example flow rates of between 10 ml / min and 1 1 / min), such flow rates permitting administration of NO in invasive or non-invasive ventilated adult, infant and neonatal patients - the built-in pressure relief valve has a rupture disc and / or thermal fuse which ensures an increased safety of use by allowing pressurized gas to escape to the atmosphere in the event that an accidental combustion, such as a fire, occurs. produced in the storage room of the gas cylinder equipped with said RDI The invention also relates to an installation for delivering a gas containing NO to a patient comprising a fan delivering an oxygen-containing gas, a system for storing and dispensing a gaseous mixture formed of NO / N 2 according to the invention, a patient circuit fluidly connected to the fan, and a device for NO distribution to control the amount of NO / N2 from the storage and distribution system and released into the patient circuit. In addition, the invention also relates to a method for dispensing a NO / N2 mixture, in which a system for storing and dispensing a gaseous mixture of NO / N2 according to the invention or a distribution installation is used. a gas containing NO to a patient according to the invention. The present invention will now be better understood thanks to the description given hereinafter with reference to the appended figures in which: FIG. 1 is an embodiment of an NO distribution installation fed by a gas conditioning system according to and Figure 2 is a block diagram of an integrated pressure reducer (RDI) valve of a gas storage and distribution system according to the present invention. The storage and dispensing system according to the invention can be used to supply an NO distribution facility to patients suffering from pulmonary vasoconstriction, for example via the NO delivery facility, an embodiment of which is shown diagrammatically in FIG. This installation comprises a fan 1 with a breathing circuit or patient circuit 2 with two branches, that is to say with an inspiratory branch 3 and an exhalation branch 4. The inspiratory branch 3 is designed to convey respiratory gas from the ventilator 1 to the patient P, while the expiratory limb 4 is designed to route the exhaled gas from the patient P to the ventilator 1. At the patient P, the administration of the gas is by means of a patient interface 11 for example a respiratory mask, a tracheal cannula or nasal goggles.
    [0006] The fan 1 is fed, via a connection line 10, with an oxygen-containing gas, for example air (content of 02 of 21% by volume) or oxygen from a source of oxygen. oxygen 7, such as an oxygen cylinder or a pipe conveying oxygen from an oxygen production unit, such as a modulated pressure unit (PSA), or an oxygen storage unit, such as a buffer or storage tank. The oxygen-rich gas is delivered by the ventilator 1 in the inspiratory branch 3 of the patient circuit 2. Moreover, a device 5 for distributing NO is fluidly connected to the inspiratory branch 3 of the patient circuit 2 to deliver there via a line 12, a NO / N2 mixture, for example 200, 400, 800 or 1500 ppmv of NO and the rest being nitrogen.
    [0007] The NO delivery device 5 is itself supplied with NO / N2 mixture, via a gas supply line 9, with a container 6 of NO / N2 forming part of a storage and distribution system according to the invention. invention. The container 6 of NO / N2 is a bottle of gas, for example composite fibers, aluminum or an aluminum alloy containing 0.5, 2, 5, 10, 11 or 20 liters (water equivalent), equipped an integrated pressure reducer valve 8, preferably protected by a protective cover against shocks. The integrated pressure reducer valve 8, called "RDI", makes it possible to control the gas outlet of the container 6 and its outlet pressure, in particular by means of an expansion valve 27 and a valve seat 28.
    [0008] This RDI 8 consists of a body traversed by one or more gas passages 22 connecting a gas inlet 20 located at the attachment end of the RDI on the neck of the bottle to one or more outlet connectors 21. the gas exits the RDI, after expansion, as detailed below with reference to Figure 2. Figure 2 shows an embodiment of an integrated pressure reducer valve or "RDI" stainless steel designed to be mounted on a gaseous mixture conditioning container of NO and nitrogen, in particular by screwing on the neck of a gas cylinder.
    [0009] This RDI 8 comprises a valve body 23 (seen in section) comprising an internal gas passage 22 connecting, on the one hand, a gas inlet 20 through which the NO / nitrogen mixture is extracted from the body of the gas cylinder 6 , on which is mounted this RDI 8, and, on the other hand, one or more gas outlets 21, that is to say the gas outlet connections, through which the NO / nitrogen mixture exits the RDI 8, before being conveyed to the patient P, as explained above with reference to FIG. 1. Advantageously, it comprises two gas outlet connectors 21, 21a, 21b comprising: a first outlet connector 21a called 'in pressure ', which delivers gas at low pressure between 1 and 10 bar, on which gas delivery devices are connected, and - a second outlet connection 21b which delivers gas flow rates to predetermined volumes so as to provide different gas flow rates, for example from 5 to 20 different flow rates, typically from 10 to 15 different rates, depending on the patient considered, for example adult or child. One or more control members 24, such as a rotary wheel that can be manipulated by an operator, make it possible to control the release of the gas and to select the desired flow rate. It is therefore a gas flow selector. In order to minimize the corrosion of the elements of the RDI 8 due to the corrosive nature of the gaseous NO / nitrogen mixture, the body 23 of the RDI 8 is wholly or partly, but preferably entirely, made of stainless steel. In fact, stainless steel is used as a constituent material of the passages and other elements in contact with the NO-based gas. Thus, the gas passage (s) are in particular pierced through stainless steel parts of the body 23 of the IDR 8. Similarly, preferably, the expansion valve 27 and / or the valve seat 28, and / or other elements, are also made of stainless steel.
    [0010] The RDI 8 further comprises a manometer 25 and a filling connector 26 for filling the bottle 6 with gas when it is empty, that is to say that all the gas has been consumed. The RDI 8 comprises or may furthermore comprise other conventional components, such as springs, seals, etc.
    [0011] In addition, the NO 5 dispensing device makes it possible in particular to control the amount of NO / N2 released in the inspiratory branch 3, as well as the mode of release of this mixture, that is to say continuously or pulsed , for example only during the inspiratory phases of the patient P. It is therefore in the inspiratory branch 3, a dilution of the NO / N2 mixture with the rich 02 gas distributed by the fan 1. The dilution is a function of the content of the initial NO / N2 mixture but also the concentration of gas to be administered to the patient.
    权利要求:
    Claims (15)
    [0001]
    REVENDICATIONS1. System for storing and dispensing a NO / N2 gas mixture comprising: - a gas conditioning vessel (6) containing a gas mixture of NO and nitrogen, and - an integrated pressure reducing valve (8) comprising a metal valve body (D) comprising a gas inlet (20), at least one gas outlet (21; 21a, 21b) and at least one internal gas passage (22) passing through said valve body (23) for fluidically connecting the gas inlet (20) to the at least one gas outlet (21; 21a, 2b), said integrated pressure reducing valve (8) being attached to the conditioning container (6), characterized in that at least the portion of the valve body (23) traversed by said internal gas passage (22) is made of stainless steel.
    [0002]
    2. System according to the preceding claim, characterized in that the body (23) of the valve is entirely stainless steel.
    [0003]
    3. System according to one of the preceding claims, characterized in that the container (6) of conditioning is cylindrical and comprises a bottom and a neck with an outlet port at which is fixed the container (6) conditioning , preferably the integrated pressure reducing valve (8) is protected by a protective cover.
    [0004]
    4. System according to one of the preceding claims, characterized in that the integrated pressure reducing valve (8) further comprises means for adjusting the expansion of the gas.
    [0005]
    5. System according to one of the preceding claims, characterized in that the integrated pressure regulator valve (8) further comprises means for controlling the release of the gas.
    [0006]
    6. System according to one of the preceding claims, characterized in that the means for adjusting the expansion of the gas and / or the gas release control means comprise one or more rotary members (24) manually actuatable by a user. .
    [0007]
    7. System according to one of the preceding claims, characterized in that the means for adjusting the expansion of the gas cooperate with a valve (27) for expansion, preferably the valve (27) cooperates with a seat (28) of valve .
    [0008]
    8. System according to one of the preceding claims, characterized in that the valve (27) for expansion and / or the valve seat (28) are made of stainless steel.
    [0009]
    9. System according to one of the preceding claims, characterized in that the container (6) conditioning at an internal volume less than or equal to 20 liters (equivalent water).
    [0010]
    10. System according to one of the preceding claims, characterized in that it comprises a device for monitoring the autonomy of the bottle volume (liters) and / or time (h or min).
    [0011]
    11. System according to one of the preceding claims, characterized in that the integrated pressure reducing valve (8) comprises an outlet connection for the low pressure gas and adjustable flow rate.
    [0012]
    12. System according to one of the preceding claims, characterized in that the integrated pressure regulator valve (8) comprises an outlet connector for the low-pressure gas and adjustable flow comprising keying means.
    [0013]
    13. System according to one of the preceding claims, characterized in that the integrated pressure reducing valve (8) further comprises a given flow output connection comprising one or more selectable calibrated orifices to allow delivery of gaseous NO to fixed flow rate. not adjustable.
    [0014]
    14. Installation for dispensing a gas containing NO to a patient comprising: - a ventilator (1) delivering an oxygen-containing gas; - a storage and distribution system for a gaseous mixture formed of NO / N2 according to one of the preceding claims, - a patient circuit (2) fluidly connected to the fan (1), and - a device (5) for dispensing NO for controlling the amount of NO / N2 from the storage system and distribution and released into the patient circuit (2).
    [0015]
    15. A method for dispensing a NO / N2 mixture, wherein a NO / N2 gaseous mixture storage and distribution system according to one of claims 1 to 13 or a distribution system of an NO-containing gas to a patient according to claim 14.
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    FR2990858A1|2013-11-29|NO / NITROGEN GAS MIXTURE WITH HIGH NO CONTENT TO TREAT SEVERE HYPOXEMIANT BREATHING RESTRICTIONS
    同族专利:
    公开号 | 公开日
    CN106415109B|2019-04-05|
    SG11201604703RA|2016-07-28|
    WO2015086946A1|2015-06-18|
    NO3080510T3|2018-06-02|
    FR3015000B1|2016-05-27|
    US20170259027A1|2017-09-14|
    AU2014363284B2|2018-10-18|
    CA2933528A1|2015-06-18|
    PT3080510T|2018-02-26|
    ES2659574T3|2018-03-16|
    DK3080510T3|2018-02-26|
    CN106415109A|2017-02-15|
    ZA201604332B|2017-08-30|
    JP2017500510A|2017-01-05|
    AU2014363284A1|2016-07-14|
    JP6511447B2|2019-05-15|
    EP3080510A1|2016-10-19|
    EP3080510B1|2018-01-03|
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    法律状态:
    2015-12-21| PLFP| Fee payment|Year of fee payment: 3 |
    2016-12-22| PLFP| Fee payment|Year of fee payment: 4 |
    2017-12-21| PLFP| Fee payment|Year of fee payment: 5 |
    2019-12-19| PLFP| Fee payment|Year of fee payment: 7 |
    2020-12-23| PLFP| Fee payment|Year of fee payment: 8 |
    2021-12-24| PLFP| Fee payment|Year of fee payment: 9 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1362490A|FR3015000B1|2013-12-12|2013-12-12|SYSTEM FOR STORING AND DISPENSING NO / NITROGEN MIXTURES|FR1362490A| FR3015000B1|2013-12-12|2013-12-12|SYSTEM FOR STORING AND DISPENSING NO / NITROGEN MIXTURES|
    AU2014363284A| AU2014363284B2|2013-12-12|2014-11-28|System for storing and distributing an NO/nitrogen gaseous mixture|
    CA2933528A| CA2933528A1|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    SG11201604703RA| SG11201604703RA|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    JP2016537522A| JP6511447B2|2013-12-12|2014-11-28|System for storing and distributing NO / nitrogen mixed gas|
    CN201480067092.3A| CN106415109B|2013-12-12|2014-11-28|For storing and distributing the NO/ system of nitrogen gaseous mixture|
    US15/102,587| US20170259027A1|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    PCT/FR2014/053084| WO2015086946A1|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    DK14821754.0T| DK3080510T3|2013-12-12|2014-11-28|SYSTEM FOR STORAGE AND DISTRIBUTION OF A GAS-NO / NITROGEN MIXTURE|
    PT148217540T| PT3080510T|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    ES14821754.0T| ES2659574T3|2013-12-12|2014-11-28|Storage and dispensing system for a NO / nitrogen gas mixture|
    NO14821754A| NO3080510T3|2013-12-12|2014-11-28|
    EP14821754.0A| EP3080510B1|2013-12-12|2014-11-28|System for storing and distributing an no/nitrogen gaseous mixture|
    ZA2016/04332A| ZA201604332B|2013-12-12|2016-06-27|System for storing and distributing an no/nitrogen gaseous mixture|
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